Classifications: antibiotic; azole antifungal;
Therapeutic: antifungal antibiotic

Prototype: Fluconazole
Pregnancy Category: C


2% cream


Antifungal that belongs to the azole class of antifungals. It is believed that azole antifungals act primarily by inhibiting cytochrome P450–dependent synthesis of ergosterol, a key component of the cell membrane of fungi resulting in fungal cell injury.

Therapeutic Effect

Has a broad spectrum of activity against common fungal pathogens.


Treatment of tinea pedis in immunocompetent patients.


Onychomycosis; children <12 y; pregnancy (category C).

Cautious Use

History of hypersensitivity to azole antifungals; lactation.

Route & Dosage

Tinea Pedis
Adult/Child (>12 y): Topical Apply thin layer to affected area twice daily for 4 wk


  • Cleanse the affected area and dry thoroughly before application.
  • Apply a thin layer of the cream to affected area between the toes and the immediately surrounding healthy skin. Gently rub into the skin.
  • Store at 15°–30° C (57°–86° F).

Adverse Effects (≥1%)

Skin: Contact dermatitis, dry skin, burning, application site reaction, skin tenderness.


Absorption: Negligible through intact skin.

Nursing Implications

Assessment & Drug Effects

  • Monitor for clinical improvement, which should be seen about 2 wk after initiating treatment.

Patient & Family Education

  • Report any of the following: severe skin irritation, redness, burning, blistering, or itching.
  • Do not stop using this medication prematurely. Athlete's foot takes about 4 wk to clear completely.
  • Nursing mothers should ensure that this topical cream does not accidentally get on the breast.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

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