Exsel, Selsun, Selsun Blue
Classifications: antibiotic; antifungal; Therapeutic: topical antibiotic; topical antifungal, antiseborrheic
Pregnancy Category: C
1% lotion, shampoo
Has antibacterial and mild antifungal and antiseborrheic activity. Absorption of selenium sulfide into epithelial tissue
cells is followed by degradation of compound to selenium and sulfide ions. Selenium ions block enzyme systems involved in
epithelial cell growth. As a result, rate of turnover in cells with normal or higher than normal turnover rates is reduced.
Active against Pityrosporum ovale, a yeast-like fungus found in the normal flora of the scalp. Also decreases rate of growth of the epithelial cells of the
scalp and other epithelial layers of cells in the body.
Itching and flaking of the scalp associated with dandruff, seborrheic dermatitis of the scalp, and tinea versicolor.
Kidney failure or biliary tract obstruction, GI malfunction; Wilson's disease; application to damaged or inflamed skin surfaces;
as treatment of tinea versicolor during pregnancy; pregnancy (category C) as antiseborrheic only when clearly needed; lactation,
children <2 y.
Prolonged skin contact; use in genital area or skin folds.
Route & Dosage
|Dandruff Control, Seborrheic Dermatitis
Adult/Child: Topical Massage 510 mL of a 12.5% solution into wet scalp and leave on for 23 min, rinse thoroughly, then
repeat application and rinse well again (initially, shampoo 2 times/wk for 2 wk, then decrease to once q14wk prn)
Adult/Child: Topical Apply a 2.5% solution to affected area with a small amount of water to form a lather, leave on for 10 min, then rinse
thoroughly, repeat once/d for 7 d
- Wash hands thoroughly after application of selenium sulfide to affected areas. Remove jewelry before treatment; drug will
- Rinse genital areas and skin folds well with water and dry thoroughly after treatment for tinea versicolor to prevent irritation.
- Store at 15°30° C (59°86° F) in tight container; protected from heat. Avoid freezing.
Adverse Effects (≥1%)Skin: Skin irritation (stinging),
rebound oiliness of scalp, hair discoloration, diffuse hair loss (reversible), systemic toxicity (if applied to abraded,
No percutaneous absorption if skin is intact.
Assessment & Drug Effects
- Monitor therapeutic effectiveness.
Patient & Family Education
- Rinse thoroughly with water if lotion contacts eyes in order to prevent chemical conjunctivitis.
- Do not use drug more frequently than required to maintain control of dandruff.
- Hair loss is reversible, usually within 23 wk after treatment is discontinued.
- Discontinue use if skin is irritated or treatment fails. Systemic toxicity may result from application of lotion to damaged
skin (percutaneous absorption) or from prolonged use (overdosage). Toxicity symptoms include tremors, anorexia, occasional
vomiting, lethargy, weakness, severe perspiration, garlicky breath, lower abdominal pain. Symptoms disappear 1012
d after treatment is stopped.