Classifications: rifamycin antibiotic; Therapeutic: antibiotic
Pregnancy Category: C
200 mg tablets
A rifamycin antibiotic structurally related to rifampin. Inhibits bacterial RNA synthesis by binding to DNA-dependent RNA
polymerase, thereby blocking RNA transcription.
Its spectrum of activity includes gram-positive and gram-negative aerobes and anaerobes.
Treatment of traveler's diarrhea cause by noninvasive strains of E. coli.
Hypersensitivity to rifaximin, other rifamycin antimicrobial agents or to any of its components; ulcerative intestinal disease;
dysentery; children <12 y; pregnancy (category C); lactation.
Diarrhea with fever and/or blood in the stool, or diarrhea due to organisms other than E. coli; worsening diarrhea or diarrhea persisting for >2448 h.
Route & Dosage
Adult: PO 200 mg t.i.d. for 3 d
- May be given without regard to food.
- Store at 15°30° C (59°86° F).
Adverse Effects (≥1%)Body as a Whole:
Headache. GI: Flatulence,
abdominal pain, rectal tenesmus, defecation urgency, nausea, constipation
<0.4% absorbed orally. Peak:
1.21 h. Elimination:
In feces. Half-Life:
Assessment & Drug Effects
- Withhold drug and notify physician if symptoms worsen or last >48 h after starting drug; an alternative treatment should
- Report promptly the appearance of blood in the stool.
Patient & Family Education
- Report promptly any of the following: fever; difficulty breathing; skin rash, itching, or hives; worsening diarrhea during
or after treatment or blood in the stool.