RIFAMPICIN (RIFAMPIN) AND SSRIS

In two cases rifampicin decreased the efficacy of citalopram and sertraline. In theory rifampicin could affect other SSRIs but there appear to be no reports of this.
Information is limited. The dosage adjustment of any SSRI on starting or stopping rifampicin should be guided by clinical effect. Be alert for evidence of SSRI withdrawal symptoms of loss of effect.
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