Classifications: antibiotic; pleuromutilin; Therapeutic: topical antibiotic
Pregnancy Category: B
1% (10 mg/g) topical ointment
Selectively inhibits bacterial protein synthesis at a site on the 50S subunit of the bacterial ribosome.
Antibacterial agent that is bacteriostatic against Staphylococcus aureus and Streptococcus pyogenes.
Topical treatment of impetigo due to susceptible stains of Staphylococcus aureus (methicillin-sensitive strains only) or Streptococcus pyogenes in patients 9 mo of age or older.
Hypersensitivity to retapamulin; children less than 9 mo.
Pregnancy (category B); lactation.
Route & Dosage
Adult/Child/Infant (≥9 mo): Apply in thin layer b.i.d. x 5 d
- Apply a thin layer to infected region. May cover with gauze dressing.
- Store at 15°30° C (59°86° F).
Adverse Effects (≥1%)Body as a Whole:
Application-site irritation, pyrexia. CNS:
Headache. GI: Diarrhea
, nausea. Metabolic: Creatinine
phosphokinase increased. Respiratory:
Nasopharyngitis. Skin: Eczema
Minimal systemic absorption. Metabolism:
Assessment & Drug Effects
- Monitor for excessive skin irritation. Report swelling, blistering, or oozing.
Patient & Family Education
- Report any of the following at application site: redness, itching, burning, swelling, blistering, or oozing.