QUINOLONES AND TIZANIDINE

Ciprofloxacin increases the AUC of tizanidine tenfold, which increases the hypotensive and sedative effects of tizanidine. Other quinolones may also interact, see quinolones.
Anticipate the need to reduce the tizanidine dose before starting ciprofloxacin, and closely monitor adverse effects such as marked hypotension, bradycardia, and sedation. Note that in the manufacturers contraindicate the combination.