Classifications: anthelmintic; Therapeutic: anthelmintic
Pregnancy Category: C
180 mg capsules; 50 mg/mL suspension
Exerts selective depolarizing neuromuscular blocking action, which results in spastic paralysis of worm; also inhibits cholinesterase.
Causes evacuation of worms from intestines.
Enterobius vermicularis (pinworm) and Ascaris lumbricoides (roundworm) infestations.
Hookworm infestations; trichostrongylosis.
Safety during pregnancy (category C), lactation.
Liver dysfunction; malnutrition; dehydration; anemia.
Route & Dosage
|Pinworm or Roundworm
Adult/Child: PO 11 mg/kg as a single dose (max: 1 g)
- Shake suspension well before pouring it to ensure accurate dosage.
- Give with milk or fruit juices and without regard to prior ingestion of food or time of day.
- Store below 30° C (86° F). Protect from light.
Adverse Effects (≥1%)CNS:
Dizziness, headache, drowsiness, insomnia
vomiting, abdominal distention, diarrhea
transient elevation of AST. Skin:
and pyrantel may be mutually antagonistic.
Poorly from GI tract. Peak:
13 h. Metabolism:
In liver. Elimination:
>50% in feces, 7% in urine.
Assessment & Drug Effects
- Lab tests: Monitor baseline and periodic AST/ALT in individuals with known liver dysfunction.
Patient & Family Education
- Do not drive or engage in other potentially hazardous activities until response to drug is known.