Ritonavir increases the AUC of
trazodone by more than 2-fold and sedation and
fatigue were increased. Two cases of
serotonin syndrome, have been reported in patients taking
trazodone and
ritonavir or indinavir. Other
protease inhibitors may interact similarly.
A lower dose of
trazodone should be considered if it is given with potent CYP3A4
inhibitors such as
ritonavir and indinavir, although note that in the UK it has been
suggested that the combination should be avoided where possible.