PROTAMINE SULFATE

Protamine sulfate; Antidote - Heparin; Inj: 10 mg/mL; Dose of Protamine (mg) to Time Elapsed: Neutralize 100 U of Heparin: Immediate; 1
30-60 min ; 0.5-0.75
60-120 min 0.375-0.5 >2h; 0.25-0.375
Used to treat heparin overdosage. Infuse protamine over 10 minutes. Monitor APTT and blood pressure.
Low-Molecular-Weight Heparin (LMWH) overdose:
If given within 4 hours, 1 mg per 1 mg of LMWH then repeat with 0.5mg per 1 mg of LMWH if APTT still prolonged in 2-4 hours