Fluoxetine markedly inhibits the
metabolism (5-hydroxylation) of
propafenone, and
paroxetine would also be expected to behave similarly, but the
clinical consequences
of this are unknown. Fluvoxamine would be expected to inhibit the
metabolism of
propafenone by N-dealkylation, but in most patients this is only expected to have a
small effect.
Until more is known, it would be prudent to use caution when giving fluoxetine or
paroxetine with
propafenone. Sertraline, citalopram and probably escitalopram
would not be expected to interact and an
in vitro study supports this suggestion.