Probenecid increases the
serum levels and/or decreases the urinary excretion of cinoxacin, ciprofloxacin, clinafloxacin, enoxacin, fleroxacin,
levofloxacin,
nalidixic acid and
norfloxacin.
This is unlikely to be of
clinical significance unless other drugs that affect
renal clearance are taken concurrently. Grepafloxacin, moxifloxacin, sparfloxacin, and probably
ofloxacin, appear not to interact with
probenecid.