Pred Forte, Pred Mild
PREDNISOLONE SODIUM PHOSPHATE
AK-Pred, Inflamase Forte, Inflamase Mild
Classifications: adrenal corticosteroid; glucocorticoid; Therapeutic: corticosteroid; glucocorticoid
Pregnancy Category: C
Prednisolone: 1 mg, 2.5 mg, 5 mg tablet; 5 mg/5 mL, 15 mg/5 mL syrup;
Acetate: 1% ophthalmic suspension;
Sodium Phosphate: 5 mg/5 mL liquid; 0.125%, 1%, 0.9%, 0.11% ophthalmic solution
Analog of hydrocortisone with 35 times greater potency. Mineralocorticoid properties are minimal, and potential for
sodium and water retention as well as potassium loss is reduced.
Effective as an anti-inflammatory agent.
Principally as an antiinflammatory and immunosuppressant agent.
Fungal infections; GI bleeding; pregnancy (category C).
Cataracts; coagulopathy; diabetes mellitus; seizure disorders; renal disease; psychosis; emotional instability; GI disorders.
Route & Dosage
Adult: PO 560 mg/d in single or divided doses Ophthalmic See Appendix A-1
Child: PO 0.12 mg/kg/d in divided doses
Alternate-Day Therapy (ADT) for Patient on Long-Term Therapy
- Give with meals to reduce gastric irritation. If distress continues, consult physician about possible adjunctive antacid
- With ADT, the 48-h requirement for steroids is administered as a single dose every other morning.
- Be aware that ADT minimizes adverse effects associated with long-term treatment while maintaining the desired therapeutic
- See PREDNISONE for numerous additional nursing implications.
Adverse Effects (≥1%)Endocrine:
Hirsutism (occasional), adverse effects on growth and development of the individual and on sperm. Special Senses:
Perforation of cornea (with topical drug). Body as a Whole:
Sensitivity to heat; fat embolism, hypotension and shock-like reactions. CNS: Insomnia
Gastric irritation or ulceration. Skin:
Ecchymotic skin lesions; vasomotor symptoms
. Also see PREDNISONE
, phenytoin, rifampin
increase steroid metabolism
, therefore may need increased doses of prednisolone; amphotericin B, diuretics
add to potassium
loss; ambenonium, neostigmine, pyridostigmine
may cause severe muscle weakness in patients with myasthenia gravis; vaccines
may inhibit antibody response. Food: Licorice
may elevate plasma
levels and adverse effects.
Readily from GI tract. Peak:
12 h. Duration:
11.5 d. Distribution:
Crosses placenta; distributed into breast milk. Metabolism:
In liver. Elimination:
HPA suppression: 2436 h; in urine. Half-Life:
Assessment & Drug Effects
- Be alert to subclinical signs of lack of improvement such as continued drainage, low-grade fever, and interrupted healing.
In diseases caused by microorganisms, infection may be masked, activated, or enhanced by corticosteroids. Observe and report
exacerbation of symptoms after short period of therapeutic response.
- Be aware that temporary local discomfort may follow injection of prednisolone into bursa or joint.
Patient & Family Education
- Adhere to established dosage regimen (i.e., do not increase, decrease, or omit doses or change dose intervals).
- Report gastric distress or any sign of peptic ulcer.