(PRAL a TREX ate) Brand: Folotyn
• Pralatrexate can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
• Pralatrexate is a cancer medication.
• Pralatrexate is used to treat T-cell lymphoma that has spread throughout the body.
• Pralatrexate is given for relapsed T-cell lymphoma, or after another medications have been tried without successful treatment.
• Pralatrexate may also be used for purposes not listed in this medicine guide.
• You must not receive this medicine if you are allergic to it.
• To create certain you can safely use pralatrexate, speak your doctor if you have kidney disease.
• FDA pregnancy category D. Do not use pralatrexate if you are pregnant. It could harm the unborn child. Use effective birth control to avoid pregnancy during your treatment with pralatrexate. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.
• It is not known whether pralatrexate passes into breast milk or if it could harm a nursing child. You must not breast-feed a child while you are being treated with pralatrexate.
• Pralatrexate is injected into a vein through an IV. A healthcare provider will give you this injection.
• Pralatrexate is generally given once for week for up to 6 weeks at a time. Follow your doctor's instructions.
• Your doctor may have you take folic acid supplements starting 10 days till your first doze of pralatrexate and ending 30 days after your recent doze. Your may also receive vitamin B12 injections each 8 to 10 weeks during treatment. This can help protect your blood cells from some of the side effects of pralatrexate. Follow your doctor's medicine instructions very closely.
• Pralatrexate can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
• Call your doctor for instructions if you miss an appointment for your pralatrexate injection.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Do not receive a "live" vaccine while using pralatrexate, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have:
· bone marrow suppression--fever, chills, cool or flu symptoms, pale skin, light bruising or bleeding, red or pink urine, painful mouth sores, cough, trouble breathing, feeling light-headed, rapid heart rate;
· dehydration--feeling very thirsty or hot, are unable to urinate, and have hard sweating or hot and dry skin;
· low potassium--confusion, uneven heart course, extreme thirst, heighten urination, leg discomfort, muscle weakness or limp feeling);
· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.
• General side effects may include:
· nausea, vomiting, loss of appetite, diarrhea, constipation;
· weary feeling;
· swelling; or
· mild rash or itching.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Another drugs may interact with pralatrexate, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Speak every of your health care providers about all medicines you use now and any medication you start or stop using.
• Your doctor or pharmacist can provide more information about pralatrexate.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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