POTASSIUM-SPARING DIURETICS

There is a risk of hyperkalaemia if angiotensin II receptor antagonists are given with amiloride, eplerenone, spironolactone or triamterene, particularly if other risk factors (such as advanced age, dose of spironolactone greater than 25 mg, reduced renal function and type II diabetes) are also present.
Some manufacturers recommend that the combinations be used cautiously and that serum potassium should be monitored regularly. However, other manufac- turers advise against concurrent use, which seems overly cautious, if adequate precautions are taken.
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