| PIRBUTEROL ACETATE
Classifications: beta-adrenergic agonist; bronchodilator; Therapeutic: bronchodilator
Pregnancy Category: C
0.2 mg aerosol
Exhibits preferential effect on beta2-adrenergic receptors. Stimulation of beta2-adrenoreceptors relaxes bronchospasm and increases ciliary motion. Activates the enzyme that catalyzes the conversion of
ATP to cyclic adenosine monophosphate (cAMP). Increased cAMP is associated with relaxation of bronchial smooth muscle and
inhibition of the release of histamine and other mediators of hypersensitivity from mast cells.
Effective bronchodilator and decreases the release of mediators within the mast cell that cause a hypersensitivity reaction.
Prevention and reversal of bronchospasm associated with asthma.
Hypersensitivity to pirbuterol or any other adrenergic agent such as epinephrine, albuterol, or isoproterenol; pregnancy
(category C), lactation, children <12 y.
Heart disease, irregular heartbeat; QT prolongation, AV block; high blood pressure, history of stroke or seizures; diabetes;
Parkinson's disease; thyroid disease; prostate disease; glaucoma.
Route & Dosage
Adult/Child (>12 y): Inhaled 2 inhalations (0.4 mg) q6h (max: 12 inhalations/d)
- Shake inhaler canister well immediately before using.
- Direct patient to exhale deeply, loosely close lips around mouthpiece, then inhale slowly and deeply through mouthpiece
while pressing top of canister.
- Store at 15°30° C (59°86° F).
Adverse Effects (≥1%)CNS:
Nervousness, headache, dizziness, tremor. CV:
Palpitations, tachycardia. GI:
Dry mouth, nausea, glossitis, abdominal pain, cramps, anorexia, diarrhea, stomatitis. Other:
Interactions Drug: Epinephrine
and other sympathomimetic bronchodilators
may have additive effects. beta blockers
may antagonize the effects.
5 min. Peak:
30 min. Duration:
34 h. Metabolism:
In liver. Elimination:
By kidneys. Half-Life:
Assessment & Drug Effects
- Monitor arterial blood gases and pulmonary functions periodically.
- Monitor vital signs. Report tachycardia, palpitations, and hypertension or hypotension.
Patient & Family Education
- Learn proper technique for using the inhaler.
- Report palpitations, chest pain, nervousness, tremors, or other bothersome adverse effects promptly to physician.
- Contact physician immediately if symptoms of asthma worsen or you do not respond to the usual dose.
- Adhere rigidly to dosing directions and contact physician if breathing difficulty persists.