| PENICILLIN V
PENICILLIN V POTASSIUM
Apo-Pen-VK , Beepen VK, Betapen-VK, Ledercillin VK, Nadopen-V , Novopen-VK , Penicillin VK, Pen-V, Pen-Vee K, Robicillin VK, V-Cillin K, Veetids
Classifications: beta-lactam antibiotic; natural penicillin; Therapeutic: antibiotic; beta-lactam
Prototype: Penicillin G potassium
Pregnancy Category: B
250 mg, 500 mg tablets; 125 mg/5 mL, 250 mg/5 mL suspension
Acid-stable analog of penicillin G with which it shares actions. It binds with the necessary penicillin-binding proteins
(PBP) in cell wall of bacteria interfering with cell wall synthesis and resulting in cell lysis.
Penicillin V is bactericidal, and is inactivated by penicillinase. Less active than penicillin G against gonococci and other
Mild to moderate infections caused by susceptible Streptococci, Pneumococci, and Staphylococci. Also Vincent's infection and as prophylaxis in rheumatic fever.
Hypersensitivity to any penicillin; lactation.
History of or suspected allergy (hay fever, asthma, hives, eczema) reactions; hypersensitivity to cephalosporins, beta-lactamase
inhibitors, or carbapenem; GI disease; cystic fibrosis; renal impairment, hepatic impairment; pregnancy (category B).
Route & Dosage
|Mild to Moderate Infections
Adult: PO 125500 mg q6h
Child (<12 y): PO 1550 mg/kg/d in 36 divided doses
Adult: PO 2 g 3060 min before procedure, then 500 mg q6h for 8 doses
Child (<30 kg): PO 1 g 3060 min before procedure, then 250 mg q6h for 8 doses
- Give after a meal rather than on an empty stomach; drug may be better absorbed and result in higher blood levels.
- Do not coadminister with neomycin if both drugs are being used; malabsorption of penicillin V may result.
- Shake well before pouring. Following reconstitution, oral solution is stable for 14 d under refrigeration.
Adverse Effects (≥1%)Body as a Whole:
Nausea, vomiting, diarrhea,
epigastric distress. Hypersensitivity reactions
(e.g., flushing, pruritus, urticaria or other skin eruptions, eosinophilia, anaphylaxis
; hemolytic anemia, leukopenia, thrombocytopenia, neuropathy, superinfections).
elimination; may decrease efficacy of oral contraceptives
decreases absorption. Food:
Food increases breakdown in stomach.
6073% absorbed from GI tract. Peak:
3060 min. Duration:
6 h. Distribution:
Highest levels in kidneys; crosses placenta; distributed into breast milk. Elimination:
In urine. Half-Life:
Note: See penicillin G potassium for numerous additional nursing implications.
Assessment & Drug Effects
- Obtain careful history concerning hypersensitivity reactions to penicillins, cephalosporins, and other allergens before
- Lab tests: Perform C&S tests prior to initiation and at regular intervals throughout therapy. Evaluate renal, hepatic, and
hematologic systems at regular intervals in patients receiving prolonged therapy.
Patient & Family Education
- Take penicillin V around the clock at specific intervals to maintain a constant blood level.
- Do not miss any doses and continue taking medication until it is all gone unless otherwise directed by the physician.
- Discontinue medication and promptly report to physician the onset of hypersensitivity reactions and superinfections (see
- Use specially marked measuring device to ensure accurate doses of oral liquid preparation.