PAZOPANIB

(paz OH pa nib) Brand: Votrient

Buy cheap Pazopanib

What is the most significant information I must know about pazopanib?

• You must not use this medicine if you are allergic to it, or if you have severe liver disease.

Pazopanib can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

What is pazopanib?

Pazopanib is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Pazopanib is used to treat advanced renal cell carcinoma (kidney cancer).

Pazopanib is also used to treat soft tissue sarcoma (a tumor that can develop in or near muscles, tendons, joints, organs, or blood vessels). Pazopanib is generally given after another cancer medications have been tried without successful treatment of soft tissue sarcoma.

Pazopanib may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking pazopanib?

• You must not use this medicine if you are allergic to it, or if you have severe liver disease.

• To create certain you can safely take pazopanib, speak your doctor if you have any of these another conditions:

· liver disease;

· heart malady, heart rhythm disorder;

· tall blood pressure;

· a private or family history of Long QT syndrome;

· a history of blood clot or stroke;

· a thyroid disorder;

· an ulcer or another stomach disorder;

· headaches, seizures, or vision problems;

· a head injury or bleeding in your brain within the past 6 months;

· stomach or intestinal bleeding within the past 6 months; or

· if you have had surgery within the past 7 days.

• FDA pregnancy category D. Do not use pazopanib if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.

• It is not known whether pazopanib passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using pazopanib.

How must I take pazopanib?

• Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.

• Take pazopanib on an empty stomach, at least 1 hour till or 2 hours after a meal.

• Do not crush a pazopanib tablet. Swallow the pill intact. Crushing the pill may reason your body to absorb too many of the drug at one time.

• While using pazopanib, you may need frequent blood or urine trials. Your blood pressure will also need to be checked often. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

• If you need surgery, speak the surgeon onward of time that you are using pazopanib. You may need to stop using the medication for at least 7 days till your surgery.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if your following doze is smaller than 12 hours away. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking pazopanib?

• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.

Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

• Grapefruit and grapefruit juice may interact with pazopanib and lead to potentially dangerous effects. Avoid the use of grapefruit commodity while taking pazopanib.

What are the possible side effects of pazopanib?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using pazopanib and call your doctor at once if you have:

· slow healing of a wound or surgical incision;

· dizziness, fainting, quick or pounding heartbeat;

· fever, chills, light bruising, flu symptoms, sores in your mouth and throat;

· feeling short of breath (even with mild exertion), swelling, rapid weight gain;

· bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

· nosebleed, bleeding gums;

· any wound that will not heal;

· nausea, upper stomach pain, itching, weary feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· sudden numbness or weakness (especially on one side of the body), sudden severe headache, confusion, problems with vision, speech, or balance;

· seizures (convulsions);

· sudden cough, wheezing, rapid breathing, coughing up blood;

· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;

· pain, swelling, warmth, or redness in one or both legs; or

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

• General side effects may include:

· mild nausea or vomiting, diarrhea;

· weight loss;

· changes in hair or skin color;

· joint or muscle pain;

· tumor pain, mild headache; or

· unusual or unpleasant taste in your mouth.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect pazopanib?

• Much drugs can interact with pazopanib. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with pazopanib, especially:

· ADHD medications;

· an antibiotic or antifungal medication;

· an antidepressant or medication to treat a psychiatric disorder;

· asthma or allergy medication;

· cholesterol-lowering drugs, especially simvastatin (Zocor, Simcor, Vytorin, Juvisync);

· diabetes medicine you take by mouth;

· drugs to treat erectile dysfunction;

· heart or blood pressure medications, heart rhythm medication;

· HIV or AIDS medications;

· medicines used to prevent organ transplant rejection;

· medication to treat or prevent nausea and vomiting;

· migraine headache medicines, including ergot medicines or "triptans";

· sedatives or narcotic pain medication;

· seizure medicine; or

· a steroid.

This list is not complete and much another drugs can interact with pazopanib. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about pazopanib.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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