OXICONAZOLE NITRATE

OXICONAZOLE NITRATE
(ox-i-con'a-zole)
Oxistat
Classifications: azole antifungal;
Therapeutic: antifungal

Prototype: Fluconazole
Pregnancy Category: B

Availability

1% cream, lotion

Action

Topical synthetic antifungal agent that presumably works by altering the cellular membrane of the fungi, resulting in increased membrane permeability, secondary metabolic effects, and growth inhibition.

Therapeutic Effect

Effective against fungi.

Uses

Topical treatment of tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum and Trichophyton mentagrophytes; also used for cutaneous candidiasis caused by Candida albicans and Candida tropicalis.

Contraindications

Hypersensitivity to oxiconazole.

Cautious Use

Hypersensitivity to other azole antifungals; pregnancy (category B), lactation.

Route & Dosage

Tinea and Other Dermal Infections
Adult: Topical Apply to affected area once daily in the evening

Administration

Topical
  • Apply cream to cover the affected areas once daily (in the evening).
  • Treat tinea corporis and tinea cruris for 2 wk; tinea pedis for 1 mo to reduce the possibility of recurrence.
  • Store at 15°–30° C (59°–86° F).

Adverse Effects (≥1%)

Skin: Transient burning and stinging, dryness, erythema, pruritus, and local irritation.

Interactions

Drug: No clinically significant interactions established.

Pharmacokinetics

Absorption: <0.3% is absorbed systemically.

Nursing Implications

Patient & Family Education

  • Use only externally. Do not use intravaginally.
  • Discontinue drug and contact physician if irritation or sensitivity develops.
  • Avoid contact with eyes.
  • Contact physician if no improvement is noted after the prescribed treatment period.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

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