OXICONAZOLE NITRATE
| OXICONAZOLE NITRATE (ox-i-con'a-zole) Oxistat Classifications: azole antifungal; Therapeutic: antifungal Prototype: Fluconazole Pregnancy Category: B |
Availability
1% cream, lotion
Action
Topical synthetic antifungal agent that presumably works by altering the cellular membrane of the fungi, resulting in increased membrane permeability, secondary metabolic effects, and growth inhibition.
Therapeutic Effect
Effective against fungi.
Uses
Topical treatment of tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum and Trichophyton mentagrophytes; also used for cutaneous candidiasis caused by Candida albicans and Candida tropicalis.
Contraindications
Hypersensitivity to oxiconazole.
Cautious Use
Hypersensitivity to other azole antifungals; pregnancy (category B), lactation.
Route & Dosage
| Tinea and Other Dermal Infections Adult: Topical Apply to affected area once daily in the evening |
Administration
Topical- Apply cream to cover the affected areas once daily (in the evening).
- Treat tinea corporis and tinea cruris for 2 wk; tinea pedis for 1 mo to reduce the possibility of recurrence.
- Store at 15°–30° C (59°–86° F).
Adverse Effects (≥1%)
Skin: Transient burning and stinging, dryness, erythema, pruritus, and local irritation.Interactions
Drug: No clinically significant interactions established.Pharmacokinetics
Absorption: <0.3% is absorbed systemically.Nursing Implications
Patient & Family Education
- Use only externally. Do not use intravaginally.
- Discontinue drug and contact physician if irritation or sensitivity develops.
- Avoid contact with eyes.
- Contact physician if no improvement is noted after the prescribed treatment period.
Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; 
Canadian drug name; 
Prototype drug