| OSELTAMIVIR PHOSPHATE
Classifications: antiviral agent; Therapeutic:antiviral
Pregnancy Category: C
30 mg, 45 mg, 75 mg capsule; 12 mg/mL suspension
Inhibits influenza A and B viral neuraminidase enzyme, preventing the release of newly formed virus from the surface of
the infected cells. Inhibits replication of the influenza A and B virus.
Effectiveness indicated by relief of flu symptoms. Prevents viral spread across the mucous lining of the respiratory tract.
Treatment of uncomplicated acute influenza in adults symptomatic for no more than 2 d.
Hypersensitivity to oseltamivir; pregnancy (category C); infants <1 y or neonates. Safety in hepatic disease has not been
Renal impairment; lactation. Safety and efficacy in chronic cardiac/respiratory disease are not established.
Route & Dosage
Adult: PO 75 mg b.i.d. x 5 d
Child (112 y): PO >40 kg, 75 mg b.i.d. x 5 d 2340 kg, 60 mg b.i.d. x 5 d 1522 kg, 45 mg b.i.d. x 5 d <15 kg, 30 mg b.i.d. x 5 d
Adult/Child (>13 y): PO 75 mg qd x 7 d; begin within 2 d of contact with infected person
Clcr <30 mL/min: (treatment) 75 mg q.d. (prophylaxis) 75 mg q.o.d. or 30 mg q.d.
- Give with food to decrease the risk of GI upset.
- Start within 48 h of onset of flu symptoms.
- Take missed dose as soon as possible unless next dose is due within 2 h.
- Store at 15°30° C (59°86° F); protect from moisture, keep dry.
Adverse Effects (≥1%)Body as a Whole: Fatigue
Dizziness, headache, insomnia
, vertigo. GI:
Nausea, vomiting, diarrhea, abdominal pain. Respiratory: Bronchitis
Readily absorbed, 75% bioavailable. Distribution:
42% protein bound. Metabolism:
Extensively metabolized to active metabolite oseltamivir carboxylate by liver esterases. Elimination:
Primarily in urine. Half-Life:
12 h; oseltamivir carboxylate 610 h.
Assessment & Drug Effects
- Monitor ambulation in frail and older adult patients due to potential for dizziness and vertigo.
- Monitor children for abnormal behavior such as delirium or self-injury.
Patient & Family Education
- Contact your physician regarding the use of this drug in children.