|OPIUM, POWDERED OPIUM TINCTURE (LAUDANUM)
Deodorized Opium Tincture
Classifications: narcotic (opiate) agonist; narcotic analgesic; antidiarrheal; Therapeutic: narcotic analgesic; antidiarrheal
Pregnancy Category: C
Controlled Substance: Schedule II
10%, 2 mg/5 mL liquid
Is obtained from the unripe capsules of Papaver somniferum or Papaver album and contains several natural alkaloids including morphine, codeine, papaverine. Antidiarrheal due to inhibition of GI motility
and propulsion; leads to prolonged transit of intestinal contents, desiccation of feces, and constipation.
Antidiarrheal activity due to inhibition of GI motility.
Symptomatic treatment of acute diarrhea and to treat severe withdrawal symptoms in neonates born to women addicted to opiates.
Diarrhea caused by poisoning (until poison is completely eliminated); pregnancy (category C).
History of opiate agonist dependence; asthma; severe prostatic hypertrophy; hepatic disease; lactation.
Route & Dosage
Adult: PO 0.6 mL q.i.d. up to 1 mL q.i.d. (max: 6 mL/d)
Child: PO 0.0050.01 mL/kg q34h (max: 6 doses/24 h)
Child: PO Make a 1:25 aqueous dilution, then give 36 drops q36h as needed or 0.2 mL q3h, may increase by 0.05 mL q3h until
withdrawal symptoms are controlled, then gradually decrease dose after withdrawal symptoms have stabilized
- Do not confuse this preparation with camphorated opium tincture (paregoric), which contains only 2 mg anhydrous morphine/5
mL, thus requiring a higher dose volume than that required for therapeutic dose of Deodorized Opium Tincture.
- Give drug diluted with about one third glass of water to ensure passage of entire dose into stomach.
- Store in tight, light-resistant containers.
Adverse Effects (≥1%)GI:
Nausea and other GI disturbances. CNS: Depression
and other cns depressants
add to CNS
Variable absorption from GI tract. Distribution:
Crosses placenta; distributed into breast milk. Metabolism:
In liver. Elimination:
Assessment & Drug Effects
- Withhold medication and report to physician if respirations are 12/min or below or have changed in character and rate.
- Discontinue as soon as diarrhea is controlled; note character and frequency of stools.
- Offer small amounts of fluid frequently but attempt to maintain 30004000 mL fluid total in 24 h.
- Monitor body weight, I&O ratio and pattern, and temperature. If patient develops fever of 38.8° C (102° F) or above,
electrolyte and hydration levels may need to be evaluated. Consult physician.
Patient & Family Education
- Be aware that constipation may be a consequence of antidiarrheal therapy but that normal habit pattern usually is reestablished
with resumption of normal dietary intake.
- Note: Addiction is possible with prolonged use or with drug abuse.