There is some evidence to suggest that
celecoxib, parecoxib and rofecoxib do not normally interact with
warfarin. However, raised INRs accompanied by bleeding, particularly in the elderly, have been attributed to the use of
warfarin and
celecoxib or rofecoxib, and fluindione with rofecoxib. Etoricoxib causes a small increase in INR when it is taken with
warfarin.
Monitor the anticoagulant effect if these
NSAIDs are added to or withdrawn from
the treatment of patients taking anticoagulants.