Convulsions have been seen in patients given fenbufen with enoxacin, and several
NSAIDs with
ofloxacin or ciprofloxacin. The CSM in the UK warns that this interaction could occur with any NSAID/quinolone combination.
Convulsions are rare, so in the majority of patients concurrent use should be without problem. Epileptics, or those predisposed to convulsions, seem to be at greater risk, so avoid concurrent use or monitor very closely.