Probenecid reduces the clearance of zalcitabine and zidovudine, increasing their
serum levels.
The combination of zalcitabine and
probenecid is well tolerated, but the
incidence of adverse effects is reported to be very much increased when
probenecid is taken with zidovudine. Concurrent use need not be avoided, but monitor carefully for zidovudine
toxicity.