Conceptrol, Delfen, Emko, Gynol II, Koromex
Classifications: spermicide contraceptive; Therapeutic: spermicide contraceptive
Pregnancy Category: C
1%, 2%, 2.2%, 3.5%, 4%, 5% gel; 8%, 12.5% foam; 2.27%, 100 mg, 150 mg suppositories
Nonionic surfactant spermicidal incorporated into foams, gels, jelly, or suppositories. Immobilizes sperm by cell membrane
Applied over the cervix, blocks entrance to uterus by sperm, traps and absorbs seminal fluid, then releases the immediately
As barrier contraceptive alone or in conjunction with a vaginal diaphragm or with a condom.
Cystocele, prolapsed uterus, sensitivity or allergy to polyurethane or to nonoxynol-9; vaginitis; history of TSS; pregnancy
(category C); immediately after delivery or abortion; during menstruation.
Route & Dosage
Adult: Topical Apply or insert 3060 min before intercourse. Repeat before each intercourse.
- Apply foams, gels, jelly, cream: Fully load intravaginal applicator and insert about 2/3 of its length [7.510
cm (34 in.)] into vagina.
- Use with diaphragm: Place 13 tsp spermicide formulation in dome prior to insertion. After diaphragm is in place, additional
spermicide is recommended. Leave spermicide and diaphragm in place 6 h after intercourse.
Adverse Effects (≥1%)Urogenital: Candidiasis;
vaginal irritation and dryness; increase in vaginal infections; menstrual and nonmenstrual toxic shock syndrome (TSS).
Intravaginal azole antifungals
may inactivate the spermicides.
Spermicidal action is prompt upon contact with sperm; minimal systemic absorption.
Patient & Family Education
- Stop using nonoxynol-9 if pregnancy is suspected.
- Report symptoms of vaginal infection to physician: Burning, inflammation, intense vaginal and vulvar itching, cheesy, curd-like
discharge, painful intercourse, dysuria. Nonoxynol-9 antifungal properties are weaker than its antibacterial potency, thus
vulvovaginal candidiasis frequently occurs.
- Use spermicide before the first and every subsequent act of intercourse.