A
clinical study showed that the AUC of
nevirapine was reduced by 31% in patients given
rifampicin. Other information suggests that
rifampicin reduces the AUC of
nevirapine by 58%.
In the UK the combination is not advised. The US Center for Disease
Control and Prevention recommends
rifabutin, and says that
rifampicin should be used only if clearly indicated and with close monitoring.