Classifications: antibiotic; Therapeutic: antibiotic
Pregnancy Category: C
Synthetic nitrofuran related to nitrofurantoin. Acts by inhibiting aerobic and anaerobic cycles in bacterial carbohydrate
Bactericidal against most microorganisms causing surface infections, including many that have developed antibiotic resistance.
Effective against gram-positive and gram-negative bacteria.
As adjunctive therapy to combat bacterial infection in second- and third-degree burns; to prevent infection of skin grafts
and donor sites. Has been used orally in other countries for treatment of late stage of African trypanosomiasis.
Hypersensitivity to nitrofurazone; renal impairment; pregnancy (category C).
Known or suspected renal impairment; G6PD deficiency; lactation.
Route & Dosage
|Bacterial Infections Associated with Burns or Skin Grafts
Adult: Topical Apply directly to lesion or dressings; reapply daily for second- or third-degree burns or q45d for second-degree burn
with minimum exudation
- Confine applications to the part of body being treated. With wet dressings: Protect normal skin surrounding the wound with
an agent such as sterile petrolatum, petrolatum gauze, or zinc oxide. Consult physician.
- Facilitate dressing removal by flushing the gauze with sterile isotonic saline solution.
- Consult physician regarding procedure for cleaning wound following each dressing removal.
- Preserve in tight, light-resistant container, away from heat.
Adverse Effects (≥1%)Skin: Allergic contact dermatitis,
irritation, sensitization, superinfections.
Assessment & Drug Effects
- Withhold drug and notify physician at onset of symptoms of sensitization or allergy (e.g., redness, itching, burning, swelling,
rash, failure to heal), and superinfections (e.g., black furry tongue, thrush, malodorous vaginal discharge, anogenital
Patient & Family Education
- Learn appropriate technique for applying medication to skin lesions.