| NAPHAZOLINE HYDROCHLORIDE
Ak-Con, Albalon, Allerest, Clear Eyes, Comfort, Degest-2, Nafazair, Naphcon, Privine, VasoClear, Vasocon
Classifications: eye, ear, nose and throat (eent) preparation; vasoconstrictor; alpha-adrenergic agonist; decongestant; Therapeutic: topical vasoconstrictor; decongestant
Pregnancy Category: C
0.012%, 0.02%, 0.03%, 0.1% ophthalmic solution; 0.05% nasal solution
Direct-acting imidazoline derivative with marked alpha-adrenergic activity. Differs from other sympathomimetic amines in
that systemic absorption may cause CNS depression rather than stimulation.
Produces rapid and prolonged vasoconstriction of arterioles, thereby decreasing fluid exudation and mucosal engorgement.
Nasal decongestant and ocular vasoconstrictor.
Narrow-angle glaucoma; concomitant use with MAO inhibitors or tricyclic antidepressants; pregnancy (category C), lactation.
Safe use in children <6 y has not been established.
Hypertension, cardiac irregularities, advanced arteriosclerosis; diabetes; hyperthyroidism; older adult patients.
Route & Dosage
Adult: Intranasal 2 drops or sprays of 0.05% solution in each nostril q36h for no more than 35 d Ophthalmic See Appendix A
Child: Intranasal 12 drops or sprays of 0.025% solution q36h for no more than 35 d
- Instill nasal spray with patient in upright position. If administered in reclining position, a stream rather than a spray
may be ejected, with possibility of systemic reaction.
- Minimize amount of drug swallowed by taking care not to direct the flow toward nasopharynx and by positioning patient properly
with the head tilted slightly downward.
- Store at 15°30° C (59°86° F), protect from freezing.
Adverse Effects (≥1%)Body as a Whole:
Hypersensitivity reactions, headache, nausea, weakness, sweating, drowsiness, hypothermia, coma. CV:
Hypertension, bradycardia, shock-like hypotension. Special Senses:
Transient nasal stinging or burning, dryness of nasal mucosa, pupillary dilation, increased intraocular pressure, rebound
redness of the eye.
InteractionsDrug: tricyclic antidepressants
may potentiate pressor effects.
Within 10 min. Duration:
Assessment & Drug Effects
- Watch for rebound congestion and chemical rhinitis with frequent and continued use.
- Monitor BP periodically for development or worsening of hypertension, especially with ophthalmic route.
- Overdose: Bradycardia and hypotension can result. Report promptly.
Patient & Family Education
- Do not exceed prescribed regimen. Systemic effects can result from swallowing excessive medication.
- Discontinue medication and contact physician if nasal congestion is not relieved after 5 d.
- Prevent contamination of eye solution by taking care not to touch eyelid or surrounding area with dropper tip.