Classifications: narcotic (opiate) antagonist; Therapeutic: narcotic antagonist
Pregnancy Category: C
0.02 mg/mL, 0.4 mg/mL, 1 mg/mL injection
Analog of oxymorphone. A "pure" narcotic antagonist, essentially free of agonistic (morphine-like) properties. Thus,
it produces no significant analgesia, respiratory depression, psychotomimetic effects, or miosis when administered in the
absence of narcotics and possesses more potent narcotic antagonist action.
Reverses the effects of opiates, including respiratory depression, sedation, and hypotension.
Narcotic overdosage; complete or partial reversal of narcotic depression including respiratory depression induced by natural
and synthetic narcotics and by pentazocine and propoxyphene. Drug of choice when nature of depressant drug is not known and
for diagnosis of suspected acute opioid overdosage.
Shock and to reverse alcohol-induced or clonidine-induced coma or respiratory depression.
Hypersensitivity to naloxone, naltrexone, nalmefene; respiratory depression due to nonopioid drugs; substance abuse; pregnancy
Neonates and children; known or suspected narcotic dependence; brain tumor, head trauma, increased ICP; history of substance
abuse; cardiac irritability; seizure disorders; lactation.
Route & Dosage
Adult: IV 0.42 mg, may repeat q23min up to 10 mg if necessary
Child: IV 0.010.1 mg/kg, may repeat q23min up to 10 mg if necessary
Neonate: IV/SC/IM 0.01 mg/kg, may repeat q23min
Postoperative Opiate Depression
Adult: IV 0.10.2 mg, may repeat q23min for up to 3 doses if necessary
Child: IV 0.0050.01 mg/kg, may repeat q23min up to 3 doses if necessary
PREPARE: Direct: May be given undiluted. IV Infusion: Dilute 2 mg in 500 mL of D5W or NS to yield 4 mcg/mL (0.004 mg/mL).
ADMINISTER: Direct: Give bolus dose over 1015 sec. IV Infusion: Adjust rate according to patient response.
INCOMPATIBILITIES Y-site: Amphotericin B cholesteryl complex.
- Use IV solutions within 24 h.
- Store at 15°30° C (59°86° F), protect from excessive light.
Adverse Effects (≥1%)Body as a Whole:
Reversal of analgesia, tremors, hyperventilation, slight drowsiness, sweating. CV:
Increased BP, tachycardia. GI:
Nausea, vomiting. Hematologic:
Elevated partial thromboplastin time.
Reverses analgesic effects of narcotic
2 min. Duration:
45 min. Distribution:
Crosses placenta. Metabolism:
In liver. Elimination:
In urine. Half-Life:
Assessment & Drug Effects
- Observe patient closely; duration of action of some narcotics may exceed that of naloxone. Keep physician informed; repeat
naloxone dose may be necessary.
- May precipitate opiate withdrawal if administered to a patient who is opiate dependent.
- Note: Narcotic abstinence symptoms induced by naloxone generally start to diminish 2040 min after administration and usually
disappear within 90 min.
- Monitor respirations and other vital signs.
- Monitor surgical and obstetric patients closely for bleeding. Naloxone has been associated with abnormal coagulation test
results. Also observe for reversal of analgesia, which may be manifested by nausea, vomiting, sweating, tachycardia.
Patient & Family Education
- Report postoperative pain that emerges after administration of this drug to physician.