NALOXONE HYDROCHLORIDE ![]() (nal-ox'one) ![]() Narcan Classifications: narcotic (opiate) antagonist; Therapeutic: narcotic antagonist Pregnancy Category: C |
0.02 mg/mL, 0.4 mg/mL, 1 mg/mL injection
Analog of oxymorphone. A "pure" narcotic antagonist, essentially free of agonistic (morphine-like) properties. Thus, it produces no significant analgesia, respiratory depression, psychotomimetic effects, or miosis when administered in the absence of narcotics and possesses more potent narcotic antagonist action.
Reverses the effects of opiates, including respiratory depression, sedation, and hypotension.
Narcotic overdosage; complete or partial reversal of narcotic depression including respiratory depression induced by natural and synthetic narcotics and by pentazocine and propoxyphene. Drug of choice when nature of depressant drug is not known and for diagnosis of suspected acute opioid overdosage.
Shock and to reverse alcohol-induced or clonidine-induced coma or respiratory depression.
Hypersensitivity to naloxone, naltrexone, nalmefene; respiratory depression due to nonopioid drugs; substance abuse; pregnancy (category C).
Neonates and children; known or suspected narcotic dependence; brain tumor, head trauma, increased ICP; history of substance abuse; cardiac irritability; seizure disorders; lactation.
Opiate Overdose Adult: IV 0.42 mg, may repeat q23min up to 10 mg if necessary Child: IV 0.010.1 mg/kg, may repeat q23min up to 10 mg if necessary Neonate: IV/SC/IM 0.01 mg/kg, may repeat q23min Postoperative Opiate Depression Adult: IV 0.10.2 mg, may repeat q23min for up to 3 doses if necessary Child: IV 0.0050.01 mg/kg, may repeat q23min up to 3 doses if necessary |
Intravenous PREPARE: Direct: May be given undiluted. IV Infusion: Dilute 2 mg in 500 mL of D5W or NS to yield 4 mcg/mL (0.004 mg/mL). ADMINISTER: Direct: Give bolus dose over 1015 sec. IV Infusion: Adjust rate according to patient response. INCOMPATIBILITIES Y-site: Amphotericin B cholesteryl complex. |
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