Classifications: antibiotic; antifungal;
Therapeutic: antifungal antibiotic

Prototype: Terbinafine
Pregnancy Category: B


1% cream, gel


Synthetic broad-spectrum antifungal agent that may be fungicidal depending on the organism. Interferes in the synthesis of ergosterol, the principal sterol in the fungus cell membrane. Ergosterol becomes depleted and membrane function is affected.

Therapeutic Effect

Effective against topical infections caused by fungal organisms.


Tinea pedis, tinea cruris, and tinea corporis.


Hypersensitivity to naftifine; occlusive dressing.

Cautious Use

Pregnancy (category B), lactation. Safety and efficacy in children are not established.

Route & Dosage

Tinea Infections
Adult: Topical Apply cream daily, or apply gel twice daily, up to 4 wk


  • Gently massage into affected area and surrounding skin. Wash hands before and after application.
  • Do not apply occlusive dressing unless specifically directed to do so.
  • Store at 15°–30° C (59°–86° F).

Adverse Effects (≥1%)

Skin: Burning or stinging, dryness, erythema, itching, local irritation.


No clinically significant interactions established.


Absorption: 2.5–6% absorbed through intact skin. Onset: 7 d. Metabolism: In liver. Elimination: In urine and feces. Half-Life: 2–3 d.

Nursing Implications

Assessment & Drug Effects

  • Assess for irritation or sensitivity to cream; these are indications to discontinue use.
  • Reevaluate use of drug if no improvement is noted after 4 wk.

Patient & Family Education

  • Learn correct application technique.
  • Avoid contact with eyes or mucous membranes.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

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