NAFTIFINE (naf'ti-feen)
Naftin Classifications: antibiotic; antifungal; Therapeutic: antifungal antibiotic Prototype: Terbinafine Pregnancy Category: B
|
Availability
1% cream, gel
Action
Synthetic broad-spectrum antifungal agent that may be fungicidal depending on the organism. Interferes in the synthesis
of ergosterol, the principal sterol in the fungus cell membrane. Ergosterol becomes depleted and membrane function is affected.
Therapeutic Effect
Effective against topical infections caused by fungal organisms.
Uses
Tinea pedis, tinea cruris, and tinea corporis.
Contraindications
Hypersensitivity to naftifine; occlusive dressing.
Cautious Use
Pregnancy (category B), lactation. Safety and efficacy in children are not established.
Route & Dosage
Tinea Infections Adult: Topical Apply cream daily, or apply gel twice daily, up to 4 wk
|
Administration
Topical
- Gently massage into affected area and surrounding skin. Wash hands before and after application.
- Do not apply occlusive dressing unless specifically directed to do so.
- Store at 15°30° C (59°86° F).
Adverse Effects (≥1%)
Skin: Burning or stinging, dryness,
erythema, itching, local irritation.
Interactions
No clinically significant interactions established.
Pharmacokinetics
Absorption: 2.56% absorbed through intact skin.
Onset: 7 d.
Metabolism: In liver.
Elimination: In urine and feces.
Half-Life: 23 d.
Nursing Implications
Assessment & Drug Effects
- Assess for irritation or sensitivity to cream; these are indications to discontinue use.
- Reevaluate use of drug if no improvement is noted after 4 wk.
Patient & Family Education
- Learn correct application technique.
- Avoid contact with eyes or mucous membranes.