(myoo roe MOE nab) Brand: Orthoclone OKT3
• Muromonab-CD3 is given as an injection through a needle placed into a vein. You will receive this injection just till your transplant and again 4 days afterward. The medication should be given slowly through an IV infusion, and can take up to 30 minutes to complete.
• Some people receiving a muromonab-CD3 injection have had a reaction to the infusion (within 30 to 60 minutes after the medication is injected into the vein). Speak your caregiver right away if you feel chilled or feverish, nauseated, weak, shaky, or light-headed, or if you have a headache, or joint and muscle aches. These side effects may also occur up to different hours after your injection.
• Muromonab-CD3 can lower the blood cells that help your body fight infections. This can create it easier for you to bleed from an injury or get sick from being near others who are ill. To be certain your blood cells do not get too low, your blood will need to be tested on a regular basis. It is significant that you not miss any scheduled visits to your doctor after your transplant.
• Avoid contact with people who have colds, the flu, or another contagious illnesses. Contact your doctor immediately if you develop signs of infection.
• Avoid receiving a vaccine or flu shot shortly after you have been treated with muromonab-CD3, unless your doctor has told you to.
• There may be another drugs that can affect muromonab-CD3. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.
• Muromonab-CD3 lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a kidney. This is because the immune system treats the new organ as an invader.
• Muromonab-CD3 is used with another medications to prevent organ rejection after a kidney transplant.
• Muromonab-CD3 may also be used for another purposes not listed in this medicine guide.
• You must not be given this medicine if you are allergic to muromonab or mouse proteins, or if you have:
· heart failure;
· untreated or uncontrolled tall blood pressure (hypertension);
· epilepsy or another seizure mess; or
· if you are pregnant or breast-feeding.
• Till receiving muromonab-CD3, speak your doctor if you are allergic to any drugs, or if you have:
· chest pain (angina);
· congestive heart failure;
· a breathing disorder;
· a history of heart onslaught or stroke; or
· if you have recently taken a diuretic ("water pill").
• If you have any of these conditions, you may need a doze adjustment or particular trials to safely receive muromonab-CD3.
• FDA pregnancy category C. This medicine may be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.
• It is not known whether muromonab-CD3 passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
• Muromonab-CD3 is given as an injection through a needle placed into a vein. You will receive this injection just till your transplant and again 4 days afterward. The medication should be given slowly through an IV infusion, and can take up to 30 minutes to complete.
• You may also be given a steroid medicine till you receive muromonab-CD3.
• Muromonab-CD3 can lower the blood cells that help your body fight infections. This can create it easier for you to bleed from an injury or get sick from being near others who are ill. To be certain your blood cells do not get too low, your blood will need to be tested on a regular basis. It is significant that you not miss any scheduled visits to your doctor after your transplant.
• Since muromonab-CD3 is given while you are in the hospital, it is unlikely that you will miss a dose.
• An overdose of muromonab-CD3 is not expected to manufacture life-threatening symptoms.
• Avoid contact with people who have colds, the flu, or another contagious illnesses. Contact your doctor immediately if you develop signs of infection.
• Avoid receiving a vaccine or flu shot shortly after you have been treated with muromonab-CD3, unless your doctor has told you to.
• Some people receiving a muromonab-CD3 injection have had a reaction to the infusion (within 30 to 60 minutes after the medication is injected into the vein). Speak your caregiver right away if you feel chilled or feverish, nauseated, weak, shaky, or light-headed, or if you have a headache, or joint and muscle aches. These side effects may also occur up to different hours after your injection.
• Speak your caregivers right away if you have any of these serious side effects:
· wheezing, gasping, shortness of breath;
· quick or uneven heart course, chest pain or hard feeling, pain spreading to the hand or shoulder, sweating, common ill feeling;
· confusion, hallucinations, unusual thoughts or behavior;
· fever, headache, neck stiffness, chills, heighten sensitivity to light;
· loss of vision or muscle control;
· seizure (black-out or convulsions);
· pain or burning when you urinate;
· light bruising or bleeding, unusual weakness; or
· tall fever, chills, stomach pain, vomiting, diarrhea, tremors, body aches, flu symptoms.
• Smaller serious side effects may include:
· mild headache;
· nausea, constipation, upset stomach;
· sleep problems (insomnia); or
· swelling in your hands, ankles, or feet.
• This is not a complete list of side effects and others may occur. Speak your doctor about any unusual or bothersome side effect. You may message side effects to FDA at 1-800-FDA-1088.
• Till receiving muromonab-CD3, speak your doctor if you are using any drugs that weaken your immune system, such as:
· cyclosporine (Neoral, Sandimmune, Gengraf);
· basiliximab (Simulect), efalizumab (Raptiva);
· azathioprine (Imuran), leflunomide (Arava), etanercept (Enbrel);
· steroids such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others;
· sirolimus (Rapamune), tacrolimus (Prograf);
· mycophenolate mofetil (CellCept);
· azathioprine (Imuran), leflunomide (Arava), etanercept (Enbrel); or
· any type of chemotherapy or radiation treatment.
• This list is not complete and there may be another drugs that can interact with muromonab-CD3. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about muromonab-CD3.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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