Bactroban, Bactroban Nasal
Classifications: pseudomonic acid antibiotic; Therapeutic: antibiotic
Pregnancy Category: B
2% ointment; cream
Topical antibacterial produced by fermentation of Pseudomonas fluorescens. Inhibits bacterial protein synthesis by binding with the bacterial transfer RNA.
Susceptible bacteria are Staphylococcus aureus [including methicillin-resistant (MRSA) and beta-lactamase-producing strains] and other Staphylococcus and Streptococcus pyogenes.
Impetigo due to Staphylococcus aureus, beta-hemolytic Streptococci, and Streptococcus pyogenes; nasal carriage of S. aureus.
Superficial skin infections; burns.
Hypersensitivity to any of its components and for ophthalmic use; lactation (do not apply to breast); children <12 y (intranasal
form); moderate to severe renal impairment.
Pregnancy (category B), lactation.
Route & Dosage
Adult/Child: Topical Apply to affected area t.i.d., if no response in 35 d, reevaluate (usually continue for 12 wk)
Elimination of Staphylococcal Nasal Carriage
Child: Intranasal Apply intranasally b.i.d. to q.i.d. for 514 d
- Apply thin layer of medication to affected area.
- Cover area being treated with a gauze dressing if desired.
Adverse Effects (≥1%)Skin:
Burning, stinging, pain, pruritus, rash, erythema, dry skin, tenderness, swelling. Special Senses:
Intranasal, local stinging, soreness, dry skin, pruritus.
Incompatible with salicylic acid 2%
; do not mix in hydrophilic vehicles
) or coal tar solutions
may interfere with bactericidal action of mupirocin.
Not systemically absorbed.
Assessment & Drug Effects
- Watch for signs and symptoms of superinfection (see Appendix F). Prolonged or repeated therapy may result in superinfection
by nonsusceptible organisms.
- Reevaluate drug use if patient does not show clinical response within 35 d.
- Discontinue the drug and notify physician if signs of contact dermatitis develop or if exudate production increases.
Patient & Family Education
- Discontinue drug and contact physician if a sensitivity reaction or chemical irritation occurs (e.g., increased redness,