Moclobemide markedly inhibits the
metabolism of rizatriptan, modestly inhibits the
metabolism of
zolmitriptan and approximately doubles the bioavailability of
sumatriptan. Note that there is a potential risk of
serotonin syndrome, if
triptans are given with
moclobemide.
The manufacturers contraindicate the use of
moclobemide with rizatriptan or
sumatriptan. In the UK, a maximum intake of 5 mg of
zolmitriptan in 24 hours is recommended by the manufacturers, whereas in the US the combination is contraindicated.