A number of studies suggest that no interaction, or only a moderate non-significant rise in tricyclic antidepressant levels occurs when they are given with
moclobemide.
However, several case reports describe
serotonin syndrome, in patients
receiving the combination. It seems likely that
trazodone will also interact in this way.
Concurrent use is not advised.
Moclobemide has a short duration of action so no
treatment free period is required before starting
trazodone. However, some recommend waiting 24 hours.
Moclobemide should not be started until at least one week after
trazodone has been stopped.