Some studies suggest that
moclobemide may not interact with the
SSRIs, but there have been case reports of
serotonin syndrome, in patients taking the combination.
Concurrent use is contraindicated. Because the effects of
moclobemide are readily reversible, only one day need elapse between stopping
moclobemide and starting an SSRI. However, if stopping an SSRI and starting
moclobemide the same intervals as for the irreversible
MAOIs are required. The manufacturers say that any type of MAOI should not be added until sertraline has been stopped for 14 days, or citalopram, escitalopram,
fluvoxamine or
paroxetine have been stopped for 7 days, (14 days in the US). The manufacturers of fluoxetine recommend that at least 5 weeks should elapse between stopping the fluoxetine and starting the MAOI. A longer interval is suggested if long-term or high-dose fluoxetine has been used.