One report suggests that on the basis of animal studies the combination of
moclobemide and pethidine (meperidine) should be avoided or used with caution. A report of suspected
serotonin syndrome in a patient given pethidine (meperidine) in addition to her usual treatment with moclobemide, nortriptyline and
lithium, adds some weight to this suggestion. Similar predictions have been made for tramadol, and
serotonin syndrome, has been seen in a patient given tramadol with
moclobemide and clomipramine.
Concurrent use should be avoided or undertaken with great caution.