Limited evidence suggests that blood pressure elevations may occur when patients taking
moclobemide are given
nasal decongestants with indirect sympathomimetic actions, such as ephedrine. However, these rises in blood pressure do not seem to be as large as those seen with the non-selective
MAOIs. Ephedrine has been successfully and uneventfully used in the presence of
moclobemide (omitted on the day of surgery) during anaesthesia to
control hypotension.
The manufacturers of
moclobemide advise avoiding drugs such as ephedrine, pseudoephedrine and phenylpropanolamine.