Classifications: prostaglandin; Therapeutic:prostaglandin
Pregnancy Category: X
100 mcg, 200 mcg tablets
Synthetic prostaglandin E1 analog, with both antisecretory (inhibiting gastric acid secretion) and mucosal protective properties. Increases bicarbonate
and mucosal protective properties. Inhibits basal and nocturnal gastric acid secretion and acid secretion in response to
a variety of stimuli, including meals, histamine, pentagastrin, and coffee. Produces uterine contractions that may endanger
pregnancy and cause a miscarriage.
Inhibits basal and nocturanal gastric acid secretion.
Prevention of NSAID (including aspirin-induced) gastric ulcers in patients at high risk of complications from a gastric
ulcer (e.g., the older adult and patients with a concomitant debilitating disease or a history of ulcers). Drug is taken
for the duration of NSAID therapy and does not interfere with the efficacy of the NSAID.
Short-term treatment of duodenal ulcers; cervical ripening and induction of labor.
History of allergies to prostaglandins; Topical Use: abnormal fetal position, caesarean section, ectopic pregnancy; fetal disease, incomplete abortion multiparity, placenta
previa, vaginal bleeding; pregnancy (category X), lactation.
Renal impairment; inflammatory bowel disease. Safety in children <18 y is not established.
Route & Dosage
|Prevention of NSAID-Induced Ulcers
Adult: PO 100200 mcg q.i.d. p.c. and h.s. or 200 mcg b.i.d. or t.i.d.
- Give with food to minimize GI adverse effects (manufacturer recommendation).
- Store away from heat, light, and moisture.
Adverse Effects (≥1%)CNS:
Headache. GI: Diarrhea, abdominal pain,
nausea, flatulence, dyspepsia, vomiting, constipation
Spotting, cramps, dysmenorrhea, uterine contractions.
InteractionsDrug: magnesium-containing antacids
may increase diarrhea.
Readily from GI tract; extensive first pass metabolism. Onset:
30 min. Peak:
6090 min. Duration:
At least 3 h. Metabolism:
In liver. Elimination:
Primarily in urine; small amount in feces. Half-Life:
Assessment & Drug Effects
- Monitor for diarrhea; may be minimized by giving drug after meals and at bedtime. Diarrhea is a common adverse effect that
is dose related and usually self-limiting (often resolving in 8 d).
Patient & Family Education
- Avoid using concurrent magnesium-containing antacids because of increased incidence of diarrhea.
- Report postmenopausal bleeding to physician; it may be drug related.
- Avoid pregnancy during misoprostol therapy; use an effective contraception method while taking drug.
- Drug has abortifacient property. Contact physician and immediately discontinue drug if you become pregnant.