METHYLPHENIDATE AND SSRIS

Isolated reports describe delirium in one patient and a seizure in another when methylphenidate was taken with sertraline.
The clinical significance of this interaction is unknown, but bear it in mind in case of an unexpected response to treatment. Note that the use of methylphenidate with SSRIs (fluoxetine, paroxetine, sertraline) has been reported to be beneficial and without significant adverse effects.
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