| METHSCOPOLAMINE BROMIDE
Classifications: anticholinergic; antimuscarinic; antispasmodic; Therapeutic: antispasmodic; anticholinergic
Pregnancy Category: C
2.5 mg tablets
Methscopolamine decreases GI tone and decreases amplitude and frequency of peristaltic contractions of the esophagus, stomach,
duodenum, jejunum, ileum, and colon. Greater selectivity in blocking vagal impulses from GI tract than either scopolamine
Its spasmolytic and antisecretory actions are quantitatively similar to those of atropine but they last longer.
Adjunct in treatment of peptic ulcer, irritable bowel syndrome, and a variety of other GI conditions. Also may be used to
control excessive sweating and salivation, migraine headaches, and premenstrual cramps.
Hypersensitivity to any of the drug's constituents; prostatic hypertrophy; pyloric obstruction; intestinal atony; tachycardia,
cardiac disease; MS; pyloric stenosis; pregnancy (category C), lactation.
Older adult and debilitated patients; chronic pulmonary diseases (COPD).
Route & Dosage
|Irritable Bowel Syndrome
Adult: PO 2.55 mg 30 min a.c. and h.s.
- Give 30 min before meals and at bedtime.
- Preserve in tight, light-resistant containers.
Adverse Effects (≥1%) GI:
Dry mouth, constipation
. Special Senses:
Blurred vision. CNS:
Dizziness, drowsiness, flushing of skin. Urogenital:
Urinary hesitancy or retention.
InteractionsDrug: Amantadine, tricyclic antidepressants
increase anticholinergic effects; may increase effects of atenolol, digoxin;
may decrease effectiveness of phenothiazines
Erratic after PO administration
Approximately 1 h. Duration:
46 h. Elimination:
Primarily in urine and bile; some unchanged drug excreted in feces.
Assessment & Drug Effects
- Incidence and severity of adverse effects are generally dose related. Dosage is usually maintained at a level that produces
slight dryness of mouth.
- Report urinary retention promptly; may indicate discontinuation.
Patient & Family Education
- Do not drive or engage in potentially hazardous activities until response to drug is known.
- Make position changes slowly and in stages.
- Learn measures to relieve dry mouth; rinse mouth frequently with water, suck hard candy.