Classifications: retinoid; Therapeutic: depigmenting agent; retinoid
Pregnancy Category: X
Mequinol is a depigmenting agent and tretinoin is a retinoid used to improve dermatologic changes (e.g., fine wrinkling,
mottled hyperpigmentation, roughness) associated with photo-damage and aging. Mequinol's mechanism of depigmentation is probably
due to oxidation by tyrosine to cytotoxic products in melanocytes, and/or inhibition of melanin formation. Tretinoin, a
retinoid, is used to improve photo-damage to the skin by acting via retinoic acid receptors (RARs).
Mequinol has depigmenting properties; tretinoin improves sun damaged skin.
Treatment of solar lentigines (age spots).
Pregnancy (category X), lactation, children, hypersensitivity to mequinol, tretinoin.
History of hypersensitivity to acitretin, isotretinoin, etretinate, or other vitamin A derivatives, or hydroquinone; patients
with eczema, moderate to severe skin pigmentation, vitiligo; concurrent use of photosensitive medications (e.g., thiazide
diuretics, fluoroquinolones, phenothiazines, sulfonamides), concurrent use of astringents; cold weather; eczema; vitiligo.
Route & Dosage
Adult: Topical Apply to solar lentigines b.i.d. at least 8 h apart
- Apply doses at least 8 h apart; avoid application to unaffected areas.
- Avoid contact with eyes, lips, mucus membranes, or paranasal creases.
- Protect from light.
Adverse Effects (≥1%)Skin: Erythema, burning, stinging, tingling, desquamation, pruritus,
skin irritation, temporary hypopigmentation, rash, dry skin, crusting, application site reaction.
InteractionsDrug: thiazide diuretics
may augment phototoxicity.
4.4% through skin. Peak:
Assessment & Drug Effects
Patient & Family Education
- Do not apply larger than recommended amounts.
- Do not wash affected area for at least 6 h after drug application; do not apply cosmetics to affected area for at least
30 min after drug application.
- Minimize exposure to sunlight or sunlamps. Use extra caution if also taking concurrently other drugs that are photosensitizing
(e.g., thiazide diuretics, phenothiazines).
- Notify physician if vitiligo (hypopigmentation of skin) or S&S of tretinoin toxicity develop (see ASSESSMENT & DRUG EFFECTS).