Classifications: anthelmintic; Therapeutic: anthelmintic
Pregnancy Category: C
100 mg tablets
Carbamate with unusually broad spectrum of anthelmintic activity. Inhibits formation of worm's microtubules and inhibits
glucose and other nutrient uptake by susceptible helminths.
Effective against susceptible helminths (nematodes) by interfering with their survival.
Treatment of Trichuris trichiura (whipworm), Enterobius vermicularis (pinworm), Ascaris lumbricoides (roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.
Beef, dwarf, and pork tapeworm and threadworm infections.
Safety during pregnancy (category C), or in children <2 y is not established.
Inflammatory bowel disease, ulcerative colitis, Crohn's disease; hepatic disease; lactation.
Route & Dosage
Adult: PO 100 mg as single dose
Child: PO 100 mg as single dose
Adult: PO 100 mg b.i.d. x 3 d
Child: PO 100 mg b.i.d. x 3 d
- Allow tablets to be chewed and swallowed, or crushed and mixed with food if needed.
Adverse Effects (≥1%)GI:
Transient abdominal pain, diarrhea. Body as a Whole:
Dizziness, fever (possibly due to tissue necrosis in cysts).
Interactions Drug: Carbamazepine, phenytoin
can increase metabolism of mebendazole.
Minimal from GI tract (210% of dose). Metabolism:
Metabolized to inactive metabolite. Elimination:
Primarily in feces. Half-Life:
Assessment & Drug Effects
- Initiate second course of treatment if cure does not occur within 3 wk.
- Examine and treat all family members simultaneously because pinworms are readily transmitted from person to person.
Patient & Family Education
- Practice thorough hand washing after touching any potentially contaminated item.
- Change underclothing, bedclothes, towels, and facecloths daily; bathe frequently, preferably by showering. Infected person
should sleep alone.