Classifications: anthelmintic;
Therapeutic: anthelmintic

Pregnancy Category: C


100 mg tablets


Carbamate with unusually broad spectrum of anthelmintic activity. Inhibits formation of worm's microtubules and inhibits glucose and other nutrient uptake by susceptible helminths.

Therapeutic Effect

Effective against susceptible helminths (nematodes) by interfering with their survival.


Treatment of Trichuris trichiura (whipworm), Enterobius vermicularis (pinworm), Ascaris lumbricoides (roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Unlabeled Uses

Beef, dwarf, and pork tapeworm and threadworm infections.


Safety during pregnancy (category C), or in children <2 y is not established.

Cautious Use

Inflammatory bowel disease, ulcerative colitis, Crohn's disease; hepatic disease; lactation.

Route & Dosage

Adult: PO 100 mg as single dose
Child: PO 100 mg as single dose

Other Infestations
Adult: PO 100 mg b.i.d. x 3 d
Child: PO 100 mg b.i.d. x 3 d


  • Allow tablets to be chewed and swallowed, or crushed and mixed with food if needed.

Adverse Effects (≥1%)

GI: Transient abdominal pain, diarrhea. Body as a Whole: Dizziness, fever (possibly due to tissue necrosis in cysts).


Drug: Carbamazepine, phenytoin can increase metabolism of mebendazole.


Absorption: Minimal from GI tract (2–10% of dose). Metabolism: Metabolized to inactive metabolite. Elimination: Primarily in feces. Half-Life: 3–9 h.

Nursing Implications

Assessment & Drug Effects

  • Initiate second course of treatment if cure does not occur within 3 wk.
  • Examine and treat all family members simultaneously because pinworms are readily transmitted from person to person.

Patient & Family Education

  • Practice thorough hand washing after touching any potentially contaminated item.
  • Change underclothing, bedclothes, towels, and facecloths daily; bathe frequently, preferably by showering. Infected person should sleep alone.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

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