MASOPROCOL CREAM

MASOPROCOL CREAM (mas-o-pro'col) Actinex Classifications: skin and mucous membrane agent; antiproliferative; Therapeutic: antiproliferative; actinic keratosis agent Pregnancy Category: B

Availability

10% cream

Action

Mechanism of action of masoprocol in the treatment of actinic keratoses is unknown.

Therapeutic Effect

Antiproliferative activity against keratinocytes.

Uses

Treatment of actinic keratosis.

Unlabeled Uses

Malignant melanoma.

Contraindications

Hypersensitivity to masoprocol.

Cautious Use

Pregnancy (category B); lactation. Safety and efficacy in children are not established.

Route & Dosage

Actinic Keratosis Adult: Topical Apply to lesions b.i.d. for 14–28 d

Administration

Topical

• Use externally only. Do not apply on mucous membranes. In case of eye contact, wash eye with water immediately.
• Wash and dry affected areas before application. Gently massage into area until it is evenly distributed.
• Wash hand immediately if cream is applied without a glove.
• Do not apply occlusive dressings over cream.
• Store at 15°–30° C (59°–86° F) unless otherwise directed.

Adverse Effects (≥1%)

Skin: Inflammation, erythema, dryness, flaking, itching, burning, tightness, bleeding, edema.

Interactions

Drug: No clinically significant interactions established.

Pharmacokinetics

Absorption: <2% absorbed through intact skin. Onset: 2–4 wk.

Nursing Implications

Assessment & Drug Effects

• Assess for allergic contact dermatitis, which is an indication to discontinue.
• Report severe skin reactions of any kind to physician.

Patient & Family Education

• Learn proper technique for application of the cream.
• Be prepared for a transient local burning sensation immediately following application.
• Local skin reactions are common but usually disappear within 2 wk of discontinuing cream application.
• Be aware that this product contains sulfites.
• Masoprocol may stain clothing.

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Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug