Classifications: skin and mucous membrane agent; antiproliferative;
Therapeutic: antiproliferative; actinic keratosis agent

Pregnancy Category: B


10% cream


Mechanism of action of masoprocol in the treatment of actinic keratoses is unknown.

Therapeutic Effect

Antiproliferative activity against keratinocytes.


Treatment of actinic keratosis.

Unlabeled Uses

Malignant melanoma.


Hypersensitivity to masoprocol.

Cautious Use

Pregnancy (category B); lactation. Safety and efficacy in children are not established.

Route & Dosage

Actinic Keratosis
Adult: Topical Apply to lesions b.i.d. for 14–28 d


  • Use externally only. Do not apply on mucous membranes. In case of eye contact, wash eye with water immediately.
  • Wash and dry affected areas before application. Gently massage into area until it is evenly distributed.
  • Wash hand immediately if cream is applied without a glove.
  • Do not apply occlusive dressings over cream.
  • Store at 15°–30° C (59°–86° F) unless otherwise directed.

Adverse Effects (≥1%)

Skin: Inflammation, erythema, dryness, flaking, itching, burning, tightness, bleeding, edema.


Drug: No clinically significant interactions established.


Absorption: <2% absorbed through intact skin. Onset: 2–4 wk.

Nursing Implications

Assessment & Drug Effects

  • Assess for allergic contact dermatitis, which is an indication to discontinue.
  • Report severe skin reactions of any kind to physician.

Patient & Family Education

  • Learn proper technique for application of the cream.
  • Be prepared for a transient local burning sensation immediately following application.
  • Local skin reactions are common but usually disappear within 2 wk of discontinuing cream application.
  • Be aware that this product contains sulfites.
  • Masoprocol may stain clothing.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

© 2006-2022 Last Updated On: 11/22/2022 (0)
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