| MASOPROCOL CREAM
Classifications: skin and mucous membrane agent; antiproliferative; Therapeutic: antiproliferative; actinic keratosis agent
Pregnancy Category: B
Mechanism of action of masoprocol in the treatment of actinic keratoses is unknown.
Antiproliferative activity against keratinocytes.
Treatment of actinic keratosis.
Hypersensitivity to masoprocol.
Pregnancy (category B); lactation. Safety and efficacy in children are not established.
Route & Dosage
Adult: Topical Apply to lesions b.i.d. for 1428 d
- Use externally only. Do not apply on mucous membranes. In case of eye contact, wash eye with water immediately.
- Wash and dry affected areas before application. Gently massage into area until it is evenly distributed.
- Wash hand immediately if cream is applied without a glove.
- Do not apply occlusive dressings over cream.
- Store at 15°30° C (59°86° F) unless otherwise directed.
Adverse Effects (≥1%)Skin: Inflammation, erythema, dryness, flaking,
itching, burning, tightness, bleeding, edema.
No clinically significant interactions established.
<2% absorbed through intact skin. Onset:
Assessment & Drug Effects
- Assess for allergic contact dermatitis, which is an indication to discontinue.
- Report severe skin reactions of any kind to physician.
Patient & Family Education
- Learn proper technique for application of the cream.
- Be prepared for a transient local burning sensation immediately following application.
- Local skin reactions are common but usually disappear within 2 wk of discontinuing cream application.
- Be aware that this product contains sulfites.
- Masoprocol may stain clothing.