MAPROTILINE AND MOCLOBEMIDE

A number of studies suggest that no interaction, or only a moderate non-significant rise in tricyclic antidepressant levels occurs when they are given with moclobemide. However, several case reports describe serotonin syndrome, in patients receiving the combination. It seems likely that maprotiline will interact similarly.
Concurrent use should be avoided. Moclobemide has a short duration of action so no treatment free period is required before starting a tricyclic or related antidepressant. However, some recommend waiting 24 hours. Moclobemide should not be started until at least one week after a tricyclic or related antidepressant has been stopped.
(17)
This site is intended for general information only. The information provided on this site does not constitute medical advice and should not be relied upon. You should not act or refrain from acting on any legal or medical matter based on the content of this site.
© 2006-2025 medpill.info Last Updated On: 06/11/2025 (0.02)
×
Wait 20 seconds...!!!