Serotonin syndrome, has been reported when selegiline was given with
venlafaxine. This is in line with the manufacturers' prediction and the way that other serotonergic drugs behave with selegiline. Rasagiline is expected to interact similarly.
The manufacturers of selegiline suggest that the concurrent use of
venlafaxine should be avoided. A 2-week washout period would seem appropriate when
switching from one of these drugs to the other. The manufacturers of
rasagiline advise caution on the concurrent use of antidepressants.