Rare cases of
serotonin syndrome, and other
CNS disturbances have been seen when selegiline is given with
tricyclics. Rasagiline is expected to interact similarly.
If the combination is used the outcome should be well monitored, but the likelihood of problems seems to be small. Nevertheless, some manufacturers of selegiline advise avoiding the combination of tricyclic antidepressants and selegiline. The manufacturers of
rasagiline advise caution if it is given with antidepressants.