Although safe concurrent use of selegiline and
SSRIs has been reported in a number of patients, there are also documented cases of
serotonin syndrome. Rasagiline is expected to interact similarly.
The manufacturers of
rasagiline recommend avoiding combined use with fluoxetine and
fluvoxamine. Rasagiline should not be started for 5 weeks after stopping fluoxetine or 2 weeks after starting
fluvoxamine, and fluoxetine should not be started for 2 weeks after stopping
rasagiline. They recommend caution with other SSRI antidepressants because of this risk. The manufacturers of selegiline contraindicate the concurrent use of
SSRIs. In addition, selegiline should not be started for 5 weeks after stopping fluoxetine, 2 weeks after stopping sertraline, and one week after stopping other
SSRIs.
SSRIs should not be started for 2 weeks after stopping selegiline.