Severe hypotension has been seen in patients given selegiline with
MAOIs.
Avoid concurrent use wherever possible. If both drugs are used, monitor initial doses very carefully so hypotension can be rapidly managed. Note that one of the manufacturers of selegiline actually contraindicates concurrent use. The manu- facturers of
rasagiline contraindicate concurrent use, presumably because of the way selegiline interacts.