| MAGNESIUM SALICYLATE
Doan's Pills, Magan, Mobidin
Classifications: analgesic (salicylate), nonsteroidal antiinflammatory drug (nsaid); antipyretic; Therapeutic: nsaid, analgesic; antipyretic
Pregnancy Category: C first and second trimester; D third trimester
467 mg, 500 mg, 580 mg caplets; 545 mg, 600 mg tablets
Sodium-free salicylate derivative that is a nonsteroidal antiinflammatory drug (NSAID) with low incidence of GI irritation.
It inhibits prostaglandin synthesis. Unlike aspirin, not associated with asthmatic reactions and does not inhibit platelet
aggregation or increase bleeding time.
In equal doses, less potent than aspirin as an analgesic and antipyretic. Has antiinflammatory effects.
Relief of pain and inflammation in rheumatoid arthritis, osteoarthritis, bursitis, and other musculoskeletal disorders.
Hypersensitivity to salicylates; erosive gastritis, peptic ulcer; advanced renal insufficiency, liver damage; thrombolytic
therapy; bleeding disorders; before surgery; pregnancy (category C first and second trimester, category D third trimester);
children <12 y.
Serious acid base imbalances; renal disease, history of GI bleeding, or peptic ulcers; SLE; history of acute bronchospasm;
Route & Dosage
Adult: PO 650 mg t.i.d. or q.i.d.
Adult: PO Up to 9.6 g/d in divided doses
- Give with a full glass of water, food, or milk to minimize gastric irritation.
Adverse Effects (≥1%)Body as a Whole:
Salicylism [dizziness, drowsiness, tinnitus, hearing loss, nausea, vomiting, hypermagnesemia (with high doses in patients
InteractionsDrug: Aminosalicylic acid
increases risk of salicylate
toxicity; ammonium chloride
and other acidifying agents
elimination and increase risk of salicylate
toxicity; anticoagulantsadded risk of bleeding with anticoagulants
; carbonic anhydrase inhibitors
compound ulcerogenic effects; increases methotrexate
toxicity; low doses of salicylates
may antagonize uricosuric effects of probenecid, sulfinpyrazone.
Well absorbed from the GI tract. Peak:
20 min. Distribution:
Widely distributed with high levels of salicylic acid in liver and kidney, crosses placenta, excreted in breast milk. Metabolism:
Salicylic acid is metabolized in liver. Elimination:
In kidneys. Half-Life:
23 h with single dose, 1530 h with chronic dosing.
Assessment & Drug Effects
- Lab tests: Monitor serum magnesium levels hypermagnesemia if used in high dosages or patients with any degree of renal impairment.
- Do not use salicylates in children or teenagers with influenza or chickenpox because of association with development of Reye's
Patient & Family Education
- Report to physician promptly tinnitus, hearing loss, or dizziness.
- Do not to take aspirin-containing drugs without consent of physician.
- Check ingredients. Doan's pills may contain acetaminophen plus salicylamide.