MAGNESIUM SALICYLATE
| MAGNESIUM SALICYLATE (mag-nes'i-um) Doan's Pills, Magan, Mobidin Classifications: analgesic (salicylate), nonsteroidal antiinflammatory drug (nsaid); antipyretic; Therapeutic: nsaid, analgesic; antipyretic Prototype: Aspirin Pregnancy Category: C first and second trimester; D third trimester |
Availability
467 mg, 500 mg, 580 mg caplets; 545 mg, 600 mg tablets
Action
Sodium-free salicylate derivative that is a nonsteroidal antiinflammatory drug (NSAID) with low incidence of GI irritation. It inhibits prostaglandin synthesis. Unlike aspirin, not associated with asthmatic reactions and does not inhibit platelet aggregation or increase bleeding time.
Therapeutic Effect
In equal doses, less potent than aspirin as an analgesic and antipyretic. Has antiinflammatory effects.
Uses
Relief of pain and inflammation in rheumatoid arthritis, osteoarthritis, bursitis, and other musculoskeletal disorders.
Contraindications
Hypersensitivity to salicylates; erosive gastritis, peptic ulcer; advanced renal insufficiency, liver damage; thrombolytic therapy; bleeding disorders; before surgery; pregnancy (category C first and second trimester, category D third trimester); children <12 y.
Cautious Use
Serious acid base imbalances; renal disease, history of GI bleeding, or peptic ulcers; SLE; history of acute bronchospasm; lactation.
Route & Dosage
| Analgesic/Antipyretic Adult: PO 650 mg t.i.d. or q.i.d. Arthritic Conditions Adult: PO Up to 9.6 g/d in divided doses |
Administration
Oral- Give with a full glass of water, food, or milk to minimize gastric irritation.
Adverse Effects (≥1%)
Body as a Whole: Salicylism [dizziness, drowsiness, tinnitus, hearing loss, nausea, vomiting, hypermagnesemia (with high doses in patients with renal insufficiency)].Interactions
Drug: Aminosalicylic acid increases risk of salicylate toxicity; ammonium chloride and other acidifying agents decrease renal elimination and increase risk of salicylate toxicity; anticoagulants—added risk of bleeding with anticoagulants; carbonic anhydrase inhibitors enhance salicylate toxicity; corticosteroids compound ulcerogenic effects; increases methotrexate toxicity; low doses of salicylates may antagonize uricosuric effects of probenecid, sulfinpyrazone.Pharmacokinetics
Absorption: Well absorbed from the GI tract. Peak: 20 min. Distribution: Widely distributed with high levels of salicylic acid in liver and kidney, crosses placenta, excreted in breast milk. Metabolism: Salicylic acid is metabolized in liver. Elimination: In kidneys. Half-Life: 2–3 h with single dose, 15–30 h with chronic dosing.Nursing Implications
Assessment & Drug Effects
- Lab tests: Monitor serum magnesium levels hypermagnesemia if used in high dosages or patients with any degree of renal impairment.
- Do not use salicylates in children or teenagers with influenza or chickenpox because of association with development of Reye's syndrome.
Patient & Family Education
- Report to physician promptly tinnitus, hearing loss, or dizziness.
- Do not to take aspirin-containing drugs without consent of physician.
- Check ingredients. Doan's pills may contain acetaminophen plus salicylamide.
Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; 
Canadian drug name; 
Prototype drug