Clarithromycin and
erythromycin moderately raise the levels of
atorvastatin. Note that the
macrolides differ in their ability to inhibit CYP3A4, see
macrolides other
macrolides may interact similarly.
If concurrent use is necessary it would seem wise to warn the patient to be on the look out for
symptoms of myopathy (e.g. muscle pain or weakness). Be especially cautious in patients also taking other drugs that interact with
statins (e.g. fibrates and diltiazem). Note that the manufacturers of
telithromycin suggest avoiding concurrent use (see guidance under
simvastatin below).