Two patients had large elevations in their
sirolimus levels following the addition of
erythromycin.
This interaction is in line with the manufacturer's prediction. They also predict that other inhibitors of CYP3A4 (they name
clarithromycin and telithromycin) will interact similarly, and should be avoided. Note that the
macrolides differ in their ability to inhibit CYP3A4, see
macrolides. Other
macrolides seem less likely to interact.